March 10, 2024

¿Ha aumentado la incidencia del cáncer en el mundo?

¿Ha aumentado la incidencia del cáncer en el mundo?
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Se pronostica que para 2050 los casos de cáncer aumentarán un 77%. Encontrar una cura para esta enfermedad parece ser la causa de la especie humana. ¿Cuáles son los tratamientos que existen hoy en día?, ¿por qué no hemos podido encontrar una cura?

Para este capítulo hablamos con el médico radiólogo Germán Arango; con el exministro de salud Alejandro Gaviria; Rafael Sánchez París, Director ejecutivo del Centro de Tratamiento e Investigación sobre cáncer Luis Carlos Sarmiento Angulo; y con Lina María Trujillo, subdirectora de Atención Médica y Docencia del Instituto Nacional de Cancerología.

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The day to day is full of
urgent news, noise, polemics and fanfare.

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But for the quiet, the analysis
and what we like to call slow

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- cooking journalism are my questions.
A half- hurry program made by KFAM

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inspiring smiles. It is predicted that
by two thousand and fifty cancer cases will

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increase by seventy- seven percent.
Finding a cure for this disease seems to

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be the cause of the human species. What are the treatments that exist today,

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why we have not been able to
find a cure for this chapter.

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We spoke with radiologist Germán Arango,
with former Health Minister Alejandro Gaviria. Rafael

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Sánchez Paris, Executive Director of the
Center for Cancer Treatment and Research, Scarlos

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Sarmiento Angulo and Lina María Trujillo,
Deputy Director of Medical Care and Teaching at

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the National Cancer Institute. I am
Roberto Pombo and this is chapter seventy-

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eight of my questions. Welcome.
The human has taken all his history,

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understanding himself, the world around him
and the connection between all. Since the

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arbors of our conscience, we have
asked ourselves questions and it was not enough

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for us to be bipeds and to
have opposable thumbs. We have explored the

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world all its seas and depths,
volcanoes and its wild force and glaciers,

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jungle deserts. We study every species
with which we share the planet at some

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point in history. It wasn'
t enough for us what was around us.

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Then we looked up and looked for
explanations to what was beyond our reach

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at the time. So someone once
created a device to find out what those

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lights were all about, shining in
what we call heaven. We saw them

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moving at a pace we could predict. Then we gave them names, finding

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their characteristics. We realized our place
in the Universe, the immensity and infinity,

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of what was beyond the earth.
We have found explanations for the universe,

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its galaxies, black holes, nebulae
and stars. All that wasn'

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t enough for us. And just
as someone created a telescope to see and

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understand what was at distances and times
almost impossible to reach. Someone created a

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microscope to see what was inside us. So we did the same thing at

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quantum level, that is, not
outwards, but inwards, at the level

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of molecules and atoms. At one
point we said that that was the limit

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point, which was indivisible, the
micro thing that existed. However, as

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it seems, custom was temporary to
and someone else discovered that it could be

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seen beyond the atom and later divided
it. I am dazzled to see the

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level of knowledge we have acquired as
a species. It will seem that there

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is nothing impossible for this wonderful species
that we are, with its lights and

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shadows. And although out there,
in space so far and on a macro

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scale, there are aspects that seem
to overcome us and determine our existence,

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although around us there are depths and
elements that threaten our existence. It is

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at the atomic level within us that
there is a phenomenon that owns our fears

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and that today is a threat to
humanity, cancer cells. Cancer is not

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something new. Human beings and other
animals have had cancer throughout history and there

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are records of that disease in fossils
and most holy scriptures. Some of the

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first cancer tests are among fossilized bone
tumors, human mummies from ancient Egypt,

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and ancient manuscripts. For example,
mummies have been found with growths that suggest

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bone cancer called hostium sarcoma. The
oldest description you have did not include the

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word cancer was discovered in Egypt and
dates back to the year three thousand BC,

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in a papyrus known as Papyrus Edwin
Smith, which is part of a

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book on trauma surgery and is said
to be the first surgical treatise in history.

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This document describes eight cases of breast
tumors or ulcers that were removed by

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cauterization with a tool called a fire
drill. The paper says about the disease

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there is no treatment. It was
not until the 19th century, when the

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anesthesia appeared that the first surgeries were
performed to remove some types of cancer.

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But, even though this disease has
shared so much time with humans, understanding

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it has not been easy. One
of the many statements that have been made

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on the subject is that we all
have cancer cells, but that' s

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how we go about parts. This
disease arises from random genetic changes, called

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mutations within healthy cells acquired over time. These mutations can occur for several reasons,

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such as lifestyle choices, family predispositions, long- term existing health conditions,

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or even exposing hazardous chemicals. As
mutated cells build up, they become

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cancerous. A cell that is able
to grow without control accumulates errors in its

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DNA code, which makes a gene
or set of genes malfunction. If the

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cell also loses certain safety mechanisms this
pushes it toward cancer. In other words,

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several factors need to come together to
make a cell cancerous. And any

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cell in the body has the potential
to do so. It can be divided

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if it accumulates errors with certain genes
and if these failures cause it to grow

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out of control. According to doctors
Hugur Shain and Oslem Duressi, founders of

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the biotechnology company Biontech, these random
genetic changes that occur in cancer cells arise

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two implications. The first is that
each cancer is as unique as the individual

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it affects, that is, that
even those people who are diagnosed with the

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same type of cancer have only a
fraction of shared mutations. And the second

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implication is that each tumor is a
intricate tapestry of billions of different cells that

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constantly learn to adapt, to evade
the immune system and to resist the therapeutic

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strategies that medicine and technology has investigated
And it is that possible cures therapies,

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varying shock treatments have not been lacking
in history. Since surgeries to remove tumors,

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the use of radiation and official artis
intelligence have been part of human innovation

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to combat that inner enemy. I
looked for Dr Rafael Sánchez Paris, Executive

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Director of the Cancer Treatment and Research
Center, Juis Carlos Sarmiento Angulou, to

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better answer the big question why is
it so difficult to find a cure for

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cancer? This he told me,
cancer is not just a disease. It

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is a group of really different diseases, caused by factors sometimes different from each

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other. Therefore, at the outset
there are some more curable than others.

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In addition, today the number of
patients with advanced disease is higher than with

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early disease. When cancer is diagnosed
early, the cure percentage is higher and

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this is directly related to timely access
to health services and self- care.

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Finally, the genomic changes within the
disease are dynamic and progressive. That is,

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cells learn to survive the treatments given, which complements treatment over time.

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A recent report was published in the
journal b m Jota Oncology, which concludes,

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among other things, that the global
incidence of early- onset cancer increased

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by seventy- nine comma one percent, and the number of early- oncology

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deaths increased by twenty- seven comma
seven percent between one thousand nine hundred ninety

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- two thousand nineteen. In more
concise terms, the number of people under

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the age of 50 diagnosed with this
disease worldwide has increased by almost eighty percent

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in the last three decades alone,
and the findings of the study do not

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stop there. Projections indicated that the
overall number of incidences and deaths from early

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- onset cancer would increase by thirty- one percent and twenty- one percent

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by two thousand thirty, respectively.
And excuse me for all the bad news.

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But, according to the World Health
Organization, more than thirty- five

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million new cases are predicted for two
thousand fifty, an increase of seventy-

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seven percent, compared with the estimated
twenty million cases for two thousand twenty-

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two. All these figures of the
rapidly growing global burden of cancer reflect the

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ageing and growth of the world population, as well as changes in people'

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s exposure to risk factors of which
several are associated with socio- economic development.

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All these numbers for the future are
not encouraging A little over a month

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ago, the International Agency for Cancer
Research published the latest estimates of the global

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burden of cancer, in which they
found data like First, in only two

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thousand twenty- two there were twenty
million new cases and nine seven million deaths

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from this disease. Second, about
one in five people develop cancer throughout their

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lives and finally, about one in
nine men and one in twelve women die

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from the disease. All these numbers
of such impressive proportions leave me with many

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questions, but especially one way to
reverse all these estimates about the future incidence

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of cancer. I looked for arina
María Trujillo and assistant director of medical care

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and teaching at the National Cancer Institute. To answer this, he told me

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the first thing is to declare that
cancer is not a single disease. It

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is a word that groups different diseases
that have different origins, different causalities and,

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by that of different approach, not
only of annassic treatment, then there

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is no common strategy. The only
thing we could talk about is that we

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could change in a relatively feasible time
frame according to the calculations of interim neck

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cancer, cancer whose torino has a
global elimination strategy that, in fact,

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Cartagena is the headquarters of the Global
Forum on the Elimination of Cervical Cancer,

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in which three strategies are proposed.
Thanks to the fact that with terino neck

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cancer we know who produces it,
we have tools to diagnose it before it

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becomes cancer and we have how to
treat it properly. Once it' s

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a cancer, which we have to
prevent, vaccines against the human papillomavirus,

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which is the causal people, which
we have to diagnose in a timely manner

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before it' s a cancer,
papilloma virus tests and psitologies and we have

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how to treat it. Colombia has
enough staff and enough technology to cope with

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the different stages of cancer of Colombian
women, although cancer, as it already

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says, is an anti- disease
to what this alarming increase is due to,

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According to the authors of the study
published in bm J, oncology.

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Genetic factors are likely to influence,
but diets rich in meat, red and

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salt and low without fruits and milk, in addition to alcohol and tobacco consumption,

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are the main risk factors behind the
most common cancers among those under 50

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years of age, in addition to
physical inactivity, excess weight and high blood

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sugar levels. According to this research, I quote the changes in diet,

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lifestyle and environment since the beginning of
the 20th century that have led to an

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increase in rates and obesity. Physical
inactivity, Westernized diets, and environmental pollution

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may have affected the incidence of early
onset cancer. In addition, alcohol,

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smoking and harmful exposures during pregnancy may
also have affected closing quotes and make a

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lot of sense. Just think about
how I change the human' s life,

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his work routines, or the way
we feed or consume products such as

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alcohol, nicotine, or ultraprocessed edibles. On the latter, a study by

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the University of Viennam in collaboration with
the International Agency for Cancer Research found that

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the higher the consumption of ultraprocessed foods, the greater the risk of suffering a

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combination of chronic diseases such as cancer, diabetes or heart disease. Another of

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these changes in modern life that have
helped to increase cases of this disease is

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air pollution, as if global warming
was no longer enough. At the presidential

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symposium itself two thousand twenty- two, Professor Charles Schanton of the Francis Creek

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Institute, a biomedical research center in
London, presented an investigation that highlighted that

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the same particles that contribute to climate
change are impacting human health through an important

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mechanism that causes cancer in lung cells. The Lancet Commission on Pollution and Health

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established that all forms of pollution cause
forty- three percent of lung cancer deaths.

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Air pollution alone causes twenty- nine
percent of all lung cancer deaths and

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clear estimates give, according to WHO, ninety- nine percent are breathing unhealthy

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air. As Dr Emmanuel Ricard told
him by the voice of the French League

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against Cancer in the medium Frans van
Cat, it is mainly about pollution by

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fine particles and the gases emitted by
the saying are one of the main sources

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of these particles. However, a
study published in the British journal of cancer,

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the greatest risk factor for most cancers
is simply aging. According to the

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study, more than three quarters of
all people diagnosed with this disease in the

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UK are sixty years of age or
older, and this is because cancer is

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a disease of our genes. Fragments
of the DNA Code that contain instructions for

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all microscopic machinery within our cells and
over time, errors accumulate in this code

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and scientists can now see them imprinted
on the cancer DNA, and it is

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these errors that can drive a cell' s journey. They are reached,

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but not all are bad news.
According to the nation' s annual report

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on the cancer situation in general,
mortality rates for this disease decreased by an

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average of two comma three per cent
per year among men and an average of

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one comma nine per cent per year
among women. The overall cancer mortality rate

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in the United States declined by one
third between one thousand nine hundred and ninety

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- one and two thousand nineteen.
This is largely because fewer people smoke and

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develop lung cancer, also because as
screening tests, prevention and treatments have improved

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for all types of cancer it is, this decrease has continued and even accelerated.

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The national cancer mortality rate is falling
by about two percent each year and

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in Colombia the survival of childhood cancer
is sixty percent. Early detection is one

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of the ways in which it can
help more people survive this disease and for

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this purpose, it seems that artificial
intelligence can play a key role. It

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couldn' t be used just to
make fake videos of politicians. And that

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' s because, according to research
published in The Lancet Oncology suggests that artificial

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intelligence could diagnose cancer with twice as
much accuracy as a doctor' s biopsy.

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I looked for radiologist Germán Arango,
who already uses this technology for medical

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purposes, and asked him how artificial
intelligence can help detect cancer in a timely

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manner. This he told me.
Artificial intelligence can be significantly helped in early

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detection of cancer through various methods and
applications. The first and most important of

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these is in the analysis of diagnostic
medical images, where, especially deep learning

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has shown remarkable effectiveness in the analysis
of diagnostic medical images. Like MRIs,

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CT scans, mammograms, X-
rays. Artificial intelligence algorithms can detect abnormalities

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in images that can be indicative of
cancer, often with the accuracy that equals

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or exceeds that of human specialists.
Here it is important to highlight a new

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technique, which is total body resonance
or diamar powder, which is an advanced

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imaging technique that allows you to obtain
detailed images of the whole body in a

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single exposure, being especially valuable in
the early detection of cancer. The editing

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of artificial intelligence to the diagnostic process
of this technique substantially increases its performance and

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accuracy, taking into account that it
generates large volumes of information. Other fronts

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where artificial intelligence contributes to the early
diagnosis of cancer. These are pattern analyses,

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assisted diagnosis, personalization of detection,
research and development, and continuous dying.

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In short, artificial interedency is transforming
the field of ecological diagnosis, improving

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accuracy and efficiency in early scope detection, which can lead to better prognosis and

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higher survival rates for patients. Attempts
to overcome this disease do not begin or

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end with artificial intelligence. From surgery
to chemotherapy, treatments have become more friendly

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or less invasive. For example,
if someone was diagnosed with breast cancer 100

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years ago, doctors had to take
drastic measures, such as removing the entire

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breast, along with the underlying pectoral
muscles and all the lymph nodes in the

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armpit. However, in nineteen hundred
and sixty, a type of surgery was

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discovered that was less invasive or snomizing
the side effects. The same has happened

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with other treatments, such as radiation
therapy and chemotherapy, which over time have

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refined and refined their procedures to minimize
side effects. And, as I mentioned

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before, as well as our faces
and our actillary footprints, each case of

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cancer is unique. Researchers have discovered
many ways to reduce the negative impacts of

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treatments, adapting them to individual needs
such as modulated intensity radiation therapy, in

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which radiation rays vary in intensity strength, allowing them to shape to point to

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a precise area, either in the
exact form of a tumor, if used

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to reduce it before surgery, or
the immediate area around where there was until

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the last. In fact, the
pandemic left something good and it was that

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research to develop the vaccine against covid
nineteen inspired the use of this same molecule

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to create a vaccine against pancras cancer. Last year the results of the first

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trials in patients, a group of
sixteen people in a first batch of trials

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showed promising results. Fifty percent of
the patients had positive results for this trial

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had to create a personalized vaccine for
each patient. However, and even though

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different treatments have been tried for the
many types of cancer, accessing them is

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not always easy. The WHO Global
Survey on Universal Health Coverage and Cancer shows

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that only thirty- nine per cent
of participating countries covered basic aspects of cancer

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management as part of their basic health
services funded for all citizens, health benefit

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packages, and only 28 per cent
of participating countries additionally covered care for people

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in need of palliative care, including
pain relief in general, and not just

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cancer- related care. The case
of Colombia is not the worst, but

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neither is the best. According to
an article by the University of Rosario,

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cancer mortality rates are higher in Colombia
due to greater barriers to early diagnosis,

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which is that mortality rates are higher
in middle- and low- income countries,

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which shows that there are fewer preventive
actions and greater access barriers to diagnosis

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and early initiation of treatment. According
to the newspaper, La República with data

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from ASEMI, phase- cold and
feat, the patient with standard cancer in

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two thousand twenty a year is worth
twenty comma two million pesos, which today

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represents about twenty- six million average
of treatment per person per year. If

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the disease is already detected in metastases, it could cost up to$ 229

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million. According to Cruz, there
may be even higher costs, such as

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experimental treatments, which can cost$
10, 000 a month or last-

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line treatments. But in addition,
the country allocates nearly ten eight billion a

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year in resources to care for cancer
patients. According to figures from the National

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Cancer Institute. In Colombia, about
eighty- one thousand and five hundred ninety

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- six new cases of cancer are
detected each year and about forty- three

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hundred people die each year on account
of that disease. According to a report

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of the epidomiological panorama of anif cancer
and according to the data provided in the

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high cost account. It is evident
that for cancers with higher mortality and incidence

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mom and prostate, the national indicator
of early detection decreased. That same report

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shows another problem for Oro Comillas.
On the one hand, there are limitations

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in access for certain departments and that
in recent years the specific expenditure on detection

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has decreased, which is reflected in
a smaller proportion of cases identified in the

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early Cierro Comillas age. The document
concludes that Horo Comillas, Colombia, is

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a country whose expenditure on the disease
is mainly focusing on diagnosis and treatment but

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not on early detection. This has
a negative impact. Not only about the

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lives of patients with this disease,
but it ends up imposing high costs for

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stan closing quotes. Looking at the
picture, I have one question about how

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well or how badly Colombia is in
the fight against cancer. After that,

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I will give the question to the
former Minister of Health, Alejandro Gavilla,

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who was also a cancer patient and
he told me this. Colombia has a

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cancer prevalence of approximately 6 percent six
out of every 100 people suffering from cancer.

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This has been similar to the average
number of Latin American countries. Colombia

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to implement successful preventive policies against cancer. The most important, the most successful

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has been the anti- smoking policy, which has led to a reduction in

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the incidence of tobacco use by approximately
500, 000 people in recent years,

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a fact that has had a positive
impact, for obvious reasons, on cancer

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control. Colombia, with regard to
treatments, has also made decisive progress in

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what is known as financial protection.
Unlike in many Latin American countries, a

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low- income family in Colombia does
not have to borrow or sell its home

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to pay for cancer treatment. The
coverage of the system of more than ninety

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- five percent has, of course, been instrumental for this to happen.

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There are still difficulties and problems.
This should be recognized in the opportunity of

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treatment in two periods, the time
between the suspicion of diagnosis and the definitive

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diagnosis and the time between the definitive
diagnosis and the beginning of treatment. After

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finishing my treatment, against a non- hotking report, being Minister of Health

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and being an exercise that is anecdotal, but can be illustrative, we found

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two patients from the subsidized regimen,
a milkman from the municipality of ubate and

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a domestic employee who had been diagnosed
the same day by the same disease.

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I started treatment one hundred and twenty
days later they, on average, started

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treatment between forty and forty- five
days later the three of us finished treatment

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successfully and seven months after the treatment
started, we were declared on permission on

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February 4, World Cancer Day was
commemorated. A few days later a close

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friend died from this disease, but
he was not the first. I disagree

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with this claim that a dying cancer
patient lost the battle against the disease.

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I think it' s more of
a battle that we should all give as

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a species from the trench of science. It' s a cruel disease,

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but I' m sure that just
as we get to the moon and divide

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the atom, we' re also
going to be able to find a solution.

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But I don' t want to
leave without hearing the testimony of a

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person who has suffered from this disease. So I looked for Diana Buitrago,

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a cheerleader who' s been around
for several months with a fibroadenoma on her

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right zero, I asked her to
tell us how she' s changed her

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life to UFFF I feel the emotional
part is the strongest. Not because you

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barely read the word to Carcinoma and
googlea, because I thought I was going

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to die and I thought it was
my son. Nothing. The first thing

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he did was like starting a notebook
and I said" hue puche" if

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I remember, because I left something
for him and right now. I realize

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that since there are many treatments,
there are many researches and the chances of

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survival are too high. Look,
there was something very, very curious going

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on, and it' s that
the first week of the diagnosis I couldn

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' t sleep and I was feeling
a cold here on the back and I

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was saying poached egg is the death
that' s here next to me breathing

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in my back, but then I
really realized the simple fact of being alive

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means that death is there next to
whispering, because we can die coming down

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the stairs in the shower, a
car or a robbery. I don'

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t know there' s a thousand
ways to die. So I feel like

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cancer was like that cube, although
you' re gonna understand that, yeah,

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you' re here right now,
but you don' t know if

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you' re gonna be here tomorrow. Then I started doing the things I

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felt sorry for doing, I started
dressing the way I liked it. I

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would have liked to dress, but
I felt sorry because I said, because

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no one dresses like that. Or
and I started to do it because,

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because I die And what is it, because here it won' t matter

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to anything and to me it'
s the only one that I' m

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going to say garlic puja I didn' t and I started to think more

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about priorities. My priorities used to
be very focused on each other. They

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' re still there, but right
now, I' m before me then

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like the most important thing was to
prioritize myself and give the real importance to

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the things that deserve it time with
the people that I love not leaving anything

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for tomorrow, that is, I
know it sounds super cliche. I'

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m in that process that for medicine
and all that, because apparently, there

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is a tomorrow, but that'
s like giving the real importance here the

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time. I am Roberto Pombo and
this was chapter seventy- eight of my

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questions. See you in the next
chapter from now on. This chapter of

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my questions is available on all podcast
platforms. This episode was made possible by

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00:28:18.799 --> 00:28:25.880
Kafam, inspiring Smiles. Dirección Roberto
Pombo, Producción General, juan Abel Gutiérrez,

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00:28:26.279 --> 00:28:30.960
editorial advisor, Daniel San Pedro Espina, scripts juan Abel Gutiérrez and Johnny

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00:28:30.039 --> 00:28:37.680
Rodríguez. Field production Marcela Salazar and
Lucía Beltrán. Post- production of audio Carlos Bernar